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Updated: Aug 23, 2026

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
Published on: December 20, 2024
Improved yields for the in situ production of [11C]CH4 using a niobium target chamber
Kenneth R Buckley1, Salma Jivan, Thomas J Ruth
1TRIUMF, Vancouver, BC, Canada V6T 2A3.
Abstract:
The in situ production of [11C]CH4 using a niobium metal target chamber is described. Improved yields are observed in comparison to the previously reported aluminum conical target under similar conditions of beam energy and current. An empirical expression is proposed that quantifies the loss of yield as a function of irradiation time.
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