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Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart

M J Lenzen1, W J M Scholte op Reimer, E Boersma

  • 1Department of Cardiology, Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands.

European Heart Journal
|July 13, 2004
PubMed

Insights

Heart failure patients with preserved left ventricular function (PLVF) are older, more likely women, and have higher rates of hypertension and atrial fibrillation. Despite clinical differences, mortality remains high in both PLVF and left ventricular systolic dysfunction (LVSD) groups.

Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Limited clinical trials exist for managing chronic heart failure with preserved left ventricular function (PLVF).
  • The EuroHeart Failure Survey offers insights into PLVF patient characteristics, treatment, and outcomes compared to left ventricular systolic dysfunction (LVSD).

Purpose of the Study:

  • To compare the characteristics, treatment, and outcomes of patients with PLVF versus LVSD using EuroHeart Failure Survey data.
  • To investigate potential differences in mortality predictors and treatment effects between PLVF and LVSD cohorts.

Main Methods:

  • Secondary analysis of 6806 patients from the EuroHeart Failure Survey with measured LV function.
  • Categorization into two groups: LVSD (54%) and PLVF (46%).
  • Multivariate analysis to identify independent predictors of mortality and assess treatment effects.

Main Results:

  • PLVF patients were older, predominantly women, and more frequently had hypertension and atrial fibrillation than LVSD patients.
  • PLVF patients received less cardiovascular medication, excluding calcium antagonists.
  • LVSD was an independent predictor of mortality, but no significant difference in treatment effects on mortality was observed between the groups.

Conclusions:

  • A substantial proportion of heart failure patients in the survey exhibited PLVF.
  • Significant clinical disparities exist between PLVF and LVSD patient groups.
  • Both PLVF and LVSD are associated with high morbidity and mortality rates.
Abstract

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