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Updated: Aug 23, 2026
Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
Published on: January 20, 2015
Sex-specific development of cortical monoamine levels in mouse
Shelley Connell1, Collins Karikari, Christine F Hohmann
1Doctoral Studies Program in Math and Science Education, Morgan State University, 1700 E. Cold Spring Ln., Baltimore, MD 21251, USA.
Abstract:
Several mental health disorders exhibit sex differences in monoamine levels associated with dimorphic cortical ontogeny. Studies in rodents support the notion that monoamines can profoundly modulate morphogenesis. Here, we show significant sex and hemisphere differences in BALB/cByJ mice on postnatal day 3 for dopamine (DA) and serotonin (5-TH), supporting the notion that sex differences in early monoaminergic ontogeny may result in dimorphic cortical development. Such sex differences may also influence differential behavioral and/or clinical outcomes.
