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Updated: Aug 23, 2026
Isolation and Expansion of Adult Canine Hippocampal Neural Precursors
Published on: November 29, 2016
Expression of growth differentiation factor-5 in the developing and adult rat brain
Gerard W O'Keeffe1, Michael Hanke, Jens Pohl
1Department of Neuroscience/Anatomy, Biosciences Research Institute, National University of Ireland Cork, College Road, Cork, Ireland.
Abstract:
Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.
