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Prognostic importance of renal function in patients with early heart failure and mild left ventricular dysfunction
Tom D J Smilde1, Hans L Hillege, Adriaan A Voors
1Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands. t.d.j.smilde@thorax.azg.nl
Abstract:
We evaluated the prognostic value of renal function in an initially "untreated" population with mild heart failure and compared the prognosis of this population with a matched controlled population. During a follow-up of 13 years (mean 11.7), 90 patients (56%) died. Mortality was higher compared with a matched controlled population. Multivariate Cox regression analysis demonstrated that beside the well-established risk markers of left ventricular ejection fraction and heart rate, renal function (estimated glomerular filtration rate, hazard ratio 1.16/10 ml/min/1.73 m(2), p = 0.003) was the only additional independent predictor of cardiovascular mortality in patients with early heart failure.
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