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Keloidal basal cell carcinoma after radiation therapy
Noriyuki Misago1, Yuko Ogusu, Yutaka Narisawa
1Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan. misago@post.saga-med.ac.jp
European Journal of Dermatology : EJD
|July 13, 2004
Summary
This study describes a rare case of keloidal basal cell carcinoma (BCC) developing in an area of chronic radiation dermatitis. Keloidal BCC is presented as a distinct clinico-pathological variant of basal cell carcinoma.
Area of Science:
- Dermatopathology
- Oncology
- Radiation Oncology
Background:
- Basal cell carcinoma (BCC) is the most common type of skin cancer.
- Radiation therapy is a known risk factor for secondary malignancies, including skin cancers.
- Keloidal BCC is a rare histological subtype of BCC.
Observation:
- A 67-year-old Japanese man developed a nodule in a region of chronic radiation dermatitis.
- The nodule was located on the right preauricular area, a site previously treated with radiation therapy for tuberculosis in childhood.
- Histopathological examination revealed features consistent with keloidal basal cell carcinoma.
Findings:
- The keloidal BCC exhibited prominent, keloidal collagen bundles in the stroma.
- These collagen bundles were distinct from the surrounding actinic-damaged dermis.
- No significant radiation fibrosis was noted around the keloidal BCC lesion.
Implications:
- This case highlights keloidal BCC as a rare variant of basal cell carcinoma with specific histopathological features.
- Understanding the clinico-pathological characteristics of keloidal BCC is important for accurate diagnosis and management.
- Further research may elucidate the specific mechanisms linking radiation exposure to the development of this rare BCC subtype.