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Age-related endocrine dysfunction in nonhuman primates.

N D Goncharova1, B A Lapin

  • 1Laboratory of Endocrinology, Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi-Adler, Russia, 354376. iprim@sochi.net

Annals of the New York Academy of Sciences
|July 13, 2004
PubMed
Summary

Aging primates show altered endocrine function responses. While some basal hormone levels remain stable, others change significantly, and stress responses are delayed, indicating reduced resilience in older animals.

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[Features of endocrine function of the pancreas with aging in nonhuman primates with various types of adaptive behavior.]

Advances in gerontology = Uspekhi gerontologii·2019

Area of Science:

  • Endocrinology
  • Primate Physiology
  • Aging Research

Background:

  • The aging process affects various physiological systems, including the endocrine system.
  • Understanding age-related endocrine changes in nonhuman primates provides insights into human aging.
  • Key endocrine axes, including the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-testicular (HPT) axes, are crucial for homeostasis.

Purpose of the Study:

  • To investigate age-related changes in basal and stimulated endocrine function in aging nonhuman primates.
  • To compare endocrine system functioning in young and old baboons (Papio hamadryas) and rhesus monkeys (Macaca mulatta).
  • To assess the impact of aging on the resiliency of endocrine responses to specific stimuli.

Main Methods:

  • Studied basal and stimulated endocrine function in aging nonhuman primates (Papio hamadryas and Macaca mulatta).

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  • Evaluated functions of the pineal gland, pancreatic gland, HPA axis, and HPT axis.
  • Administered specific stimuli (LHRH, CRH, ACTH, glucose) and inhibitors to assess endocrine responses.

    • Main Results:

    • Basal activity of some endocrine functions (e.g., glucocorticoid, pancreatic) showed minimal age-related variation.
    • Other functions, such as dehydroepiandrosterone sulfate (DHEA/DHEAS) production and testicular function, significantly decreased with age.
    • Older monkeys exhibited delayed normalization of the pituitary-testicular axis, adrenal cortex, and pancreatic gland function after stimulation, and reduced HPA axis sensitivity to negative feedback.

    Conclusions:

    • Age-related changes in endocrine function responses indicate impaired resiliency in older primates.
    • These endocrine alterations may contribute to age-related functional disorders and pathology.
    • Nonhuman primate models are valuable for studying the complex interplay of aging and endocrine regulation.