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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
Early-life programming of aging and longevity: the idea of high initial damage load (the HIDL hypothesis)
Leonid A Gavrilov1, Natalia S Gavrilova
1Center on Aging, National Opinion Research Center and University of Chicago, IL 60637-2745, USA. gavrilov@longevity-science.org
Abstract:
In this study, we test the predictions of the high initial damage load (HIDL) hypothesis, a scientific idea that early development of living organisms produces an exceptionally high load of initial damage, which is comparable with the amount of subsequent aging-related deterioration accumulating during the rest of the entire adult life. This hypothesis predicts that even small progress in optimizing the early-developmental processes can potentially result in a remarkable prevention of many diseases in later life, postponement of aging-related morbidity and mortality, and significant extension of healthy life span.
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