Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CSB.DB: a comprehensive systems-biology database.

Dirk Steinhauser1, Björn Usadel, Alexander Luedemann

  • 1Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Golm, Germany. Steinhauser@mpimp-golm.mpg.de <Steinhauser@mpimp-golm.mpg.de>

Bioinformatics (Oxford, England)
|July 13, 2004
PubMed
Summary

The Comprehensive Systems-Biology Database (CSB.DB) offers co-response analyses for gene expression data in model organisms. It helps generate novel hypotheses on gene interactions beyond sequence homology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wild tomato genome assemblies reveal structural variants and repeat content act as recombination barriers.

Nature communications·2026
Same author

How can biological databases support the new UN mechanism for benefit-sharing from digital sequence information?

Scientific data·2026
Same author

Integrating cross-omics research through FAIR Digital Objects with DataPLANT.

Journal of integrative bioinformatics·2026
Same author

DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Trimmomatic: a decade of feature-rich, high-performance NGS read preprocessing.

Bioinformatics (Oxford, England)·2026
Same author

Evolving bioinformatics services - the journey of KPI metrics with Scorpion.

Journal of integrative bioinformatics·2026

Area of Science:

  • Systems biology
  • Bioinformatics
  • Genomics

Background:

  • The Comprehensive Systems-Biology Database (CSB.DB) integrates gene expression data with biochemical and physiological knowledge.
  • It focuses on transcript and metabolite profiling experiments for model organisms.

Purpose of the Study:

  • To provide tools for understanding biological complexity through data integration.
  • To offer co-response databases for key model organisms: Escherichia coli, Saccharomyces cerevisiae, and Arabidopsis thaliana.

Main Methods:

  • Bio-statistical analyses of gene expression data.
  • Large-scale co-response analyses based on public transcript profile compendia.
  • Development of statistical tools for validating co-responses.

Related Experiment Videos

Main Results:

  • CSB.DB provides access to co-response databases for three model organisms.
  • It enables inference of novel hypotheses on functional gene interactions.
  • The database facilitates the search for genes under common transcriptional control.

Conclusions:

  • CSB.DB is a valuable resource for systems biology research.
  • It supports the discovery of gene functional interactions not detectable by sequence homology.
  • The platform aids in validating and comparing co-response findings.