Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxidative stress in the placenta.

Leslie Myatt1, Xiaolan Cui

  • 1Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670526, Cincinnati, OH 45267-0526, USA. Leslie.Myatt@uc.edu

Histochemistry and Cell Biology
|July 13, 2004
PubMed
Summary

Pregnancy involves oxidative stress due to reactive oxygen species (ROS) production. Imbalances in ROS overwhelm antioxidant defenses, potentially causing pregnancy complications like preeclampsia and IUGR.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterizing glial cells missing transcription factor 1 (GCM1)'s role in regulating placental gene expression.

Placenta·2026
Same author

A new approach to discovering a broad-spectrum anti-respiratory virus drug: Tubeimoside II modulates host factor PACT to potentiate the RIG-I antiviral pathway.

Acta pharmaceutica Sinica. B·2026
Same author

Exploring possible mechanisms of antiviral effect of Shufeng Jiedu Capsule on viral pneumonia: A comprehensive analysis.

Chinese herbal medicines·2026
Same author

Evaluation of Transplant Renal Artery Stenosis by Contrast-Enhanced Ultrasonography: Comparison with Digital Subtraction Angiography.

Transplantation proceedings·2026
Same author

Differential Activation of p53-Lamin A/C and p16-Rb-Mediated Senescence Pathways in Trophoblasts From Pregnancies Complicated by Type A2 Gestational Diabetes Mellitus.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development.

Molecular biomedicine·2025

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Biology
  • Biochemistry

Background:

  • Pregnancy naturally induces oxidative stress from placental activity and reactive oxygen species (ROS) production.
  • The placenta generates various ROS, including nitric oxide and superoxide, impacting placental function and vascular reactivity.
  • Pathologic pregnancies, such as preeclampsia and intrauterine growth restriction (IUGR), exhibit excessive ROS production, overwhelming antioxidant defenses.

Purpose of the Study:

  • To review the role of oxidative stress and nitrative stress in normal and pathologic pregnancies.
  • To examine the impact of ROS on placental development, function, and pregnancy outcomes.
  • To highlight the link between oxidative stress markers and adverse pregnancy conditions.

Main Methods:

  • Literature review of studies investigating oxidative stress markers in pregnancy.
  • Analysis of placental function, trophoblast behavior, and vascular reactivity in relation to ROS.
  • Examination of evidence for oxidative stress, including lipid peroxides, isoprostanes, and antioxidant levels.

Main Results:

  • Increased oxidative stress is observed in early pregnancy with intervillous blood flow establishment and in late gestation in pregnancies with diabetes, IUGR, and preeclampsia.
  • Evidence includes elevated lipid peroxides, isoprostanes, and reduced antioxidant activity.
  • The formation of peroxynitrite from nitric oxide and superoxide contributes to nitrative stress, altering protein function and placental function in conditions like preeclampsia.

Conclusions:

  • Oxidative and nitrative stress are significant factors in placental dysfunction and adverse pregnancy outcomes.
  • Impaired antioxidant defenses exacerbate ROS-induced damage during pregnancy.
  • Understanding these mechanisms is crucial for managing pregnancy complications like preeclampsia and IUGR.

Related Experiment Videos