Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fatalities caused by TRALI.

Leslie Holness1, Maureen A Knippen, Lois Simmons

  • 1Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. Holness@cber.fda.gov

Transfusion Medicine Reviews
|July 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report.

RMD open·2017
Same author

2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups.

Arthritis & rheumatology (Hoboken, N.J.)·2017
Same author

2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups.

Annals of the rheumatic diseases·2017
Same author

2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects.

Rheumatology (Oxford, England)·2017
Same author

2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Annals of the rheumatic diseases·2017
Same author

2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Annals of the rheumatic diseases·2017

Transfusion-related acute lung injury (TRALI) caused 58 deaths between 1997-2002. Fresh frozen plasma and red blood cells were frequently implicated, with symptoms including hypoxia and shortness of breath.

Area of Science:

  • Hematology
  • Immunology
  • Critical Care Medicine

Background:

  • Transfusion-related acute lung injury (TRALI) is a serious adverse event following blood product transfusion.
  • Understanding the risk factors and clinical presentation of TRALI is crucial for patient safety.

Purpose of the Study:

  • To review fatalities associated with TRALI reported to the Center for Biologics Evaluation and Research (CBER) over a 5-year period.
  • To analyze recipient and donor characteristics, implicated blood components, and clinical symptoms in fatal TRALI cases.

Main Methods:

  • Retrospective review of TRALI fatality reports submitted to CBER from 1997 to 2002.
  • Descriptive statistical analysis of recipient demographics, diagnoses, implicated blood components, and clinical signs.
  • Analysis of donor characteristics including antibody testing (HLA and antigranulocyte antibodies).

Related Experiment Videos

Main Results:

  • Fifty-eight recipient deaths were linked to TRALI, involving 63 blood component donors.
  • Cardiovascular disease, pulmonary disorders, and cancer were common recipient diagnoses.
  • Fresh frozen plasma was implicated in 50% of cases, red blood cells in approximately 33%.
  • Common clinical symptoms included shortness of breath, frothy sputum, pulmonary infiltrates, and hypoxia.
  • The majority of tested donors had positive HLA and/or antigranulocyte antibodies.

Conclusions:

  • TRALI fatalities were not clearly associated with recipient age, sex, or transfusion reason.
  • The role of donor antibodies in TRALI requires further investigation.
  • Increased practitioner awareness of TRALI signs, symptoms, and management is essential.