Related Experiment Video

Updated: Aug 15, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

[Intraocular metastatic renal carcinoma presenting as progressive unilateral blindness]

J A Gómez Pascual1, M S Martínez Martín, R Bonilla Parrilla

  • 1Servicio de Urología, Hospital Regional de Málaga, Complejo Hospitalario Carlos Haya, Málaga.

Actas Urologicas Espanolas
|July 14, 2004
PubMed

Insights

Clear cell renal carcinoma, the most common kidney cancer, frequently metastasizes. Ocular metastasis, a rare complication, presents a diagnostic challenge in renal cell carcinoma patients.

Area of Science:

  • Oncology
  • Ophthalmology
  • Pathology

Background:

  • Clear cell renal carcinoma (CCRC) is the predominant histological subtype of kidney cancer, accounting for 70-80% of all cases.
  • Metastatic disease is a significant concern, with 25-30% of CCRC patients presenting with metastases at initial diagnosis.

Observation:

  • Ocular metastasis, while exceedingly uncommon, represents a rare but serious manifestation of advanced renal cell carcinoma.
  • This abstract highlights the rarity of ocular involvement in the context of widespread CCRC metastasis.

Findings:

  • The study underscores the low incidence of ocular metastases in patients diagnosed with renal cell carcinoma.
  • Despite the high prevalence of CCRC and its metastatic potential, the eyes are an infrequent site of secondary involvement.

Implications:

  • Early detection and management of CCRC metastases are crucial for patient outcomes.
  • The extreme rarity of ocular metastasis necessitates a high index of suspicion in specific clinical scenarios involving CCRC patients with unexplained visual symptoms.

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