Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A novel electrode array for diameter-dependent control of axonal excitability: a simulation study.

Zeng Lertmanorat1, Dominique M Durand

  • 1Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA. zxl15@cwru.edu

IEEE Transactions on Bio-Medical Engineering
|July 14, 2004
PubMed
Summary

This study demonstrates that multi-contact electrode arrays can achieve physiological nerve fiber recruitment order. This method offers a promising alternative to conventional stimulation, potentially reducing nerve damage and electrode issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcranial Focused Ultrasound Stimulation Targeting White Matter Inhibits Seizures in a Rat Model of Epilepsy.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2025
Same author

Announcing a change of leadership at Journal of Neural Engineering.

Journal of neural engineering·2025
Same author

Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem.

Epilepsia open·2025
Same author

Non-synaptic interictal epileptiform discharges propagating from CA3 to CA1 induce synaptic depression in the hippocampus.

Epilepsia open·2025
Same author

Effect of Anesthesia and Diurnal Variation on Chronic Vagus Nerve Activity in Rats.

Journal of neuroscience research·2025
Same author

Cathodal weak direct current decreases epileptic excitability with reduced neuronal activity and enhanced delta oscillations.

The Journal of physiology·2025

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Computational Biology

Background:

  • Electrical stimulation typically activates large nerve fibers before small ones, reversing physiological recruitment.
  • Existing methods to achieve physiological recruitment use long stimulus pulses, risking nerve damage and electrode corrosion.

Purpose of the Study:

  • To test the hypothesis that reshaping extracellular potential profiles with multi-contact electrodes can achieve selective nerve fiber activation.
  • To investigate diameter selectivity in nerve stimulation using computer simulations.

Main Methods:

  • Computer simulations were performed in both homogenous and realistic (dog sacral root) volume conductor models.
  • A nine-contact electrode array was used to modulate extracellular potential along axons.

Related Experiment Videos

  • Stimulation thresholds and recruitment order were analyzed for different axon diameters.

    • Main Results:

    • In homogenous media, large-diameter axons had higher excitation thresholds than small-diameter axons.
    • Simulations in a dog sacral root model showed that a nine-electrode array could activate small axons preferentially.
    • The nine-electrode array achieved a near-physiological recruitment order, with selectivity controlled by electrode separation.

    Conclusions:

    • Multi-contact electrode arrays can achieve diameter-selective activation of peripheral nerves.
    • This approach offers a method to attain physiological recruitment order, independent of pulse width.
    • The findings suggest a potential for improved neural prosthetics and therapeutic stimulation.