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Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans.

B Otto1, M Tschöp, W Heldwein

  • 1Medical Department, University Hospital Innenstadt, Ziemssenstrasse 1, 80336 Munich, Germany. Baerbel.Otto@med.uni-muenchen.de

European Journal of Endocrinology
|July 14, 2004
PubMed
Summary
This summary is machine-generated.

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Glucocorticoids, like those in Cushing's syndrome or from prednisolone, lower ghrelin levels in the blood. This suggests ghrelin does not cause Cushing's disease-related changes in body composition.

Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Metabolic Research

Background:

  • Ghrelin, a peptide hormone, regulates appetite and adiposity, primarily produced by the stomach.
  • Ghrelin influences food intake and stimulates the corticotropic system.
  • The impact of glucocorticoids on ghrelin levels remains largely unknown.

Purpose of the Study:

  • To investigate the relationship between elevated glucocorticoid levels and plasma ghrelin concentrations.
  • To determine if endogenous or exogenous hypercortisolism affects ghrelin levels.

Main Methods:

  • Plasma ghrelin levels were measured in patients with Cushing's syndrome before and after surgery.
  • Healthy controls received prednisolone, and their plasma ghrelin levels were measured before and after treatment.

Related Experiment Videos

  • Radioimmunoassay was used to quantify plasma ghrelin levels.

    • Main Results:

    • Patients with Cushing's syndrome exhibited low ghrelin levels, which increased post-surgery, correlating with decreased BMI.
    • Healthy controls showed a significant suppression of plasma ghrelin levels after prednisolone administration.
    • A strong negative correlation was observed between changes in BMI and plasma ghrelin.

    Conclusions:

    • Plasma ghrelin levels are decreased under conditions of hypercortisolism, whether endogenous or exogenous.
    • Ghrelin is unlikely to be the cause of the characteristic energy balance and body composition changes in Cushing's disease.
    • Reduced ghrelin secretion may represent a compensatory mechanism for the metabolic effects of chronic hypercortisolism.