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Related Experiment Videos

Radiotherapy of aggressive fibromatosis.

G Schmitt1, E E Mills, V Levin

  • 1Klinik für Strahlentherapie und Radiologische Onkologie, Universität Düsseldorf, Germany.

European Journal of Cancer (Oxford, England : 1990)
|January 1, 1992
PubMed
Summary

Postoperative radiotherapy for aggressive fibromatosis significantly improves outcomes, with a 75% 10-year recurrence-free survival. A dose of 60 Gy is recommended for incompletely resected or residual tumors to achieve optimal tumor control.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Aggressive fibromatosis, a locally invasive tumor, presents challenges in achieving complete surgical resection.
  • Postoperative management is crucial for preventing recurrence, especially in cases of incomplete excision or gross residual disease.

Purpose of the Study:

  • To evaluate the long-term results of postoperative radiotherapy for aggressive fibromatosis.
  • To establish dose-response relationships for radiotherapy in this patient cohort.
  • To determine optimal radiotherapy strategies for managing aggressive fibromatosis.

Main Methods:

  • Retrospective analysis of 24 patients treated with postoperative irradiation.
  • Tumor sites included pelvis, chest wall, shoulder, extremities, and head and neck.

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  • Radiation doses ranged from 28 to 64 Gy, with some patients receiving brachytherapy (192Ir implants).

    • Main Results:

    • A 10-year recurrence-free survival rate of 75% was observed.
    • A dose-response relationship was established, with an 80% persistent tumor control rate expected at 60 Gy.
    • Moderate fibrosis occurred in 21% of patients without functional impairment.

    Conclusions:

    • Postoperative radiotherapy is effective in managing aggressive fibromatosis, particularly with incompletely excised or gross residual tumors.
    • A dose of 60 Gy is recommended for optimal tumor control.
    • Further research may explore dose-volume relationships to refine treatment planning.