Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cleft hands with six metacarpals.

Neil F Jones1, Michiyuki Kono

  • 1UCLA Hand Center, Department of Orthopaedic Surgery and Division of Plastic and Reconstructive Surgery, University of California, Los Angeles 90095-9607, USA.

The Journal of Hand Surgery
|July 14, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Biomechanical Cadaveric Comparison of Three Fixation Methods for Bennett Fractures.

The Journal of hand surgery·2025
Same author

Clinical, Electrophysiological, and Intraoperative Analysis and Postoperative Success of Revision Surgery for Persistent and Recurrent Carpal Tunnel Syndrome.

Eplasty·2024
Same author

Hip Preservation and Capanna Reconstruction for Pediatric Proximal Femur Ewing Sarcoma: A Report of 2 Cases.

JBJS case connector·2024
Same author

Early Thumb Carpometacarpal Subluxation Stabilized with a Mini TightRope: A Report of Two Cases.

Journal of hand surgery global online·2024
Same author

At What Time Interval After a Sharp Nerve Laceration Is Primary Nerve Repair No Longer Possible?

The Journal of hand surgery·2023
Same author

Outcomes of Distal Radius Fractures in Solid Organ Transplant Recipients.

The Journal of hand surgery·2023
Same journal

The Diagnosis and Management of Clenched Fist Syndrome.

The Journal of hand surgery·2026
Same journal

Ultrasound-Assisted Thin Posteromedial Thigh Free Flap for Coverage of Hand and Upper-Extremity Wounds.

The Journal of hand surgery·2026
Same journal

Comparison of One- and Two-knot Techniques in Eight-Strand Flexor Tendon Repair Using Looped Sutures: A Biomechanical Study in a Porcine Model.

The Journal of hand surgery·2026
Same journal

Biomechanical Comparison of Metal Versus Suture and Screw Tension Band Technique for Olecranon Fractures.

The Journal of hand surgery·2026
Same journal

Incidence, Timing, and Predictors of Staged Contralateral Carpal Tunnel Release at Minimum Ten-Year Follow-Up from Unilateral Surgery.

The Journal of hand surgery·2026
Same journal

Upper Limb Reconstruction in Arthrogryposis Multiplex Congenita: A Systematic Review.

The Journal of hand surgery·2026
See all related articles

Children with cleft hands and 6 metacarpals demonstrate polydactyly and syndactyly, suggesting a shared developmental origin rather than a failure of formation. This finding supports a central polydactyly and osseous syndactyly hypothesis for cleft hand development.

Area of Science:

  • Developmental biology
  • Orthopedic surgery
  • Pediatric radiology

Background:

  • Cleft hand is a congenital limb malformation.
  • The etiology of cleft hand remains debated, with theories including failure of formation and polydactyly/syndactyly processes.

Purpose of the Study:

  • To investigate the radiographic features of cleft hands with 6 metacarpals.
  • To support the hypothesis that cleft hand arises from central polydactyly and osseous syndactyly, not longitudinal failure of formation.

Main Methods:

  • Screening of hand radiographs from children with upper limb deficiencies.
  • Identification of 8 children with cleft hands exhibiting 6 metacarpals.

Main Results:

  • Six cases presented with a missing middle finger, featuring a thumb and index finger separated by a V-shaped cleft from the ring and small fingers.

Related Experiment Videos

  • Two severe cases showed absence of index and middle fingers, yet possessed 6 metacarpals.

    • Conclusions:

    • The presence of polydactyly and osseous syndactyly in these cleft hands contradicts failure of formation.
    • Findings support a unified teratogenic mechanism for cleft hand, polydactyly, and syndactyly.
    • Severe cleft hand manifestations with 6 metacarpal polydactyly confirm a common failure of induction mechanism.