Related Experiment Video
Updated: Aug 23, 2026
Colonization with Murine pks+ Escherichia coli under Non-Inflammatory Conditions
Published on: March 10, 2026
Association of Streptococcus bovis bacteremia with colonic neoplasia and extracolonic malignancy
Jason S Gold1, Sancar Bayar, Ronald R Salem
1Department of Surgery, Yale University School of Medicine, New Haven, Conn. 06520, USA.
Background:
The association between Streptococcus bovis bacteremia and colonic neoplasia is well described; however, the relationship between S bovis and neoplasia outside the colon has not been well evaluated.
Hypothesis:
S bovis bacteremia may be associated with colonic neoplasia and extracolonic malignancy.
Design:
Retrospective review of all documented cases of S bovis bacteremia identified by a search of computerized bacteriology records.
Setting:
One tertiary referral hospital and 1 community hospital located in the same city.
Patients:
Forty-five patients (41 adults, 4 children) with documented S bovis bacteremia during a 12-year period were identified.
Main Outcome Measures:
Available patient records were reviewed to identify the presence of colonic neoplasia, the use of gastrointestinal endoscopy, and the presence of gastrointestinal or extraintestinal malignancies.
Results:
Seventeen patients (41% of adult patients) underwent colonoscopy. Colonic neoplasia was present in 16 patients (39% of adults), with 3 of these patients having invasive colorectal cancer (7% of adults). Invasive cancer was present in 13 patients (32% of adults). Eight patients had malignant lesions arising within the gastrointestinal tract, and 5 patients had extraintestinal malignancies.
Conclusion:
S bovis bacteremia is associated with both colonic neoplasia and extracolonic malignancy.
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