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Growth hormone secretion in diffuse idiopathic skeletal hyperostosis.
L Altomonte1, A Zoli, L Mirone
1Divisione di Reumatologia, Istituto di Clinica Medica, Università Cattolica del Sacro Cuore, Roma.
Annali Italiani Di Medicina Interna : Organo Ufficiale Della Societa Italiana Di Medicina Interna
|January 1, 1992
Summary
Patients with diffuse idiopathic skeletal hyperostosis (DISH) showed an increased growth hormone (GH) response to an intravenous insulin tolerance test (IVITT). This suggests GH may promote bone growth in DISH patients.
Area of Science:
- Endocrinology
- Bone Metabolism
- Skeletal Diseases
Background:
- Diffuse idiopathic skeletal hyperostosis (DISH) is a skeletal condition of unknown etiology.
- The role of endocrine factors, particularly growth hormone (GH), in DISH pathogenesis is not well understood.
Purpose of the Study:
- To investigate the endocrine response to glucose loading and insulin-induced hypoglycemia in patients with DISH.
- To explore the potential role of growth hormone (GH) in the bone growth associated with DISH.
Main Methods:
- Evaluated serum insulin, C-peptide, and GH levels in six non-obese DISH patients and controls.
- Administered oral glucose tolerance test (OGTT) and intravenous insulin tolerance test (IVITT).
- Compared hormonal responses between DISH patients and healthy controls.
Main Results:
- Basal insulin, C-peptide, and GH levels were comparable between DISH patients and controls.
- No significant differences in insulin and C-peptide response to OGTT were observed.
- DISH patients exhibited a significantly higher GH increase at 30 and 45 minutes post-IVITT compared to controls.
Conclusions:
- The heightened GH release in response to IVITT in DISH patients supports the hypothesis of GH involvement.
- Growth hormone may act as a bone growth-promoting factor in diffuse idiopathic skeletal hyperostosis.
- Further research is warranted to elucidate the precise mechanisms of GH action in DISH.