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Risk factors for hypertensive crisis: importance of out-patient blood pressure control
James E Tisdale1, Mike B Huang, Steven Borzak
1Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA. jtisdale@iupui.edu
Insights
Poorly controlled outpatient systolic blood pressure is a key risk factor for hypertensive crisis. This finding highlights the importance of effective blood pressure management to prevent emergency room visits.
Area of Science:
- Cardiology
- Hypertension Research
- Public Health
Background:
- Hypertensive crisis is a serious medical condition requiring emergency care.
- Identifying independent risk factors is crucial for prevention strategies.
Purpose of the Study:
- To determine independent risk factors associated with hypertensive crisis.
- To inform clinical practice and public health initiatives for hypertension management.
Main Methods:
- Retrospective, case-controlled study design.
- 143 patients with hypertensive crisis (BP >/=180/110 mmHg with symptoms) compared to 485 controls.
- Analysis of co-morbidities and outpatient blood pressure control.
Main Results:
- Inadequate outpatient systolic blood pressure control was an independent risk factor (OR 1.30, P < 0.001).
- Higher outpatient diastolic blood pressure and a history of heart failure showed trends towards significance.
- Average ED blood pressure in the crisis group was 197/108 mmHg.
Conclusions:
- Suboptimal outpatient systolic blood pressure control is a significant independent risk factor for hypertensive crisis.
- Effective outpatient blood pressure management is vital for preventing emergency department presentations.
- Further research may clarify the role of diastolic pressure and heart failure history.
Objectives:
The purpose of this study was to identify independent risk factors for development of hypertensive crisis.
Methods:
This was a retrospective, case-controlled study. Cases were 143 patients who presented during a 3-year period to the Emergency Department with the diagnosis of hypertensive crisis, defined as systolic pressure >/=180 mmHg and/or diastolic pressure >/=110 mmHg and symptoms of hypertensive emergency during the Emergency Department presentation. Controls were 485 patients with hypertension, matched to cases on the basis of age, sex and race, who were not admitted to the Emergency Department with an episode of hypertensive crisis during the study period. Co-morbid conditions were identified from computerized health system databases and medical records. Out-patient blood pressures were obtained from medical records from randomly selected out-patient clinic visits.
Results:
The average blood pressure during Emergency Department presentation in patients with hypertensive crisis was 197 +/- 21/108 +/- 14 mmHg. Less successful out-patient systolic blood pressure control was an independent risk factor for hypertensive crisis [odds ratio (OR) 1.30 (1.18-1.42), per 10 mmHg, P < 0.001]. Higher out-patient diastolic blood pressures [OR 1.21 (0.99-1.43 per 10 mmHg, P = 0.07] and history of heart failure [OR 3.48 (0.94-12.94), P = 0.06] trended towards independence as risk factors.
Conclusion:
Less effective blood pressure control, based on out-patient systolic blood pressure measurements, is an independent risk factor for an Emergency Department presentation due to hypertensive crisis.
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