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Related Experiment Video

Updated: May 31, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 10, 2014

Rapid HIV-1 testing during labor: a multicenter study.

Marc Bulterys¹, Denise J Jamieson, Mary Jo O'Sullivan

¹Division of HIV/AIDS Prevention, Surveillance and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA. mbulterys@cdc.gov

|July 14, 2004

Summary

This summary is machine-generated.

Rapid human immunodeficiency virus (HIV) testing in labor is feasible and accurate. This enables timely antiretroviral prophylaxis for HIV-positive mothers, reducing perinatal transmission.

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Area of Science:

Obstetrics and Gynecology
Infectious Diseases
Public Health

Background:

Undocumented human immunodeficiency virus (HIV) status in laboring women necessitates rapid testing for immediate antiretroviral prophylaxis.
Antiretroviral prophylaxis is crucial for reducing perinatal HIV transmission.

Purpose of the Study:

To assess the feasibility and acceptance of rapid HIV testing among women in labor.
To evaluate the performance of rapid HIV assays in this population.

Main Methods:

The Mother-Infant Rapid Intervention At Delivery (MIRIAD) study conducted voluntary rapid HIV testing in 16 US hospitals (2001-2003).
A rapid HIV-1 antibody test for whole blood was utilized, with counseling available 24/7.
Key outcomes included test acceptance, assay sensitivity, specificity, predictive values, and time to results.

Main Results:

Of 7381 eligible women without documented HIV status, 78% were approached, and 84% consented to rapid testing.
The prevalence of HIV-1 was 7/1000. Rapid test sensitivity was 100%, specificity 99.9%, and positive predictive value 90%.
Median time to results was 66 minutes, significantly faster than the 28-hour turnaround for enzyme immunoassay (EIA).

Conclusions:

Rapid HIV testing is a feasible and accurate method for identifying HIV status in laboring women.
Timely results facilitate prompt initiation of antiretroviral prophylaxis, thereby reducing perinatal HIV transmission.
This approach is particularly beneficial for higher-risk populations and improves maternal-infant health outcomes.