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Pattern of polymorphism after strong artificial selection in a domestication event.

Hideki Innan1, Yuseob Kim

  • 1Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA. hideki.innan@uth.tmc.edu

Proceedings of the National Academy of Sciences of the United States of America
|July 14, 2004
PubMed
Summary

Artificial selection during domestication can leave unique DNA signatures. The initial frequency of beneficial alleles significantly impacts how much genetic variation remains, influencing detection of selection.

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Area of Science:

  • Evolutionary genetics
  • Population genetics
  • Genomics

Background:

  • Domestication involves strong artificial selection, a process distinct from typical selective sweeps.
  • Artificial selection can act on pre-existing neutral variants, unlike selective sweeps that target new mutations.
  • Understanding genetic variation patterns is crucial for identifying domestication events.

Purpose of the Study:

  • To model the effects of artificial selection and population bottlenecks during domestication on DNA polymorphism.
  • To investigate how the initial frequency of beneficial alleles influences the reduction of genetic variation.
  • To assess the detectability of selection signatures based on polymorphism patterns.

Main Methods:

  • Development of a theoretical model for artificial selection during domestication.

Related Experiment Videos

  • Inclusion of population bottleneck effects within the domestication model.
  • Analysis of DNA polymorphism patterns resulting from varying initial allele frequencies.

    • Main Results:

    • Artificial selection during domestication does not always eliminate DNA variation in surrounding regions.
    • The extent of variation reduction is strongly dependent on the initial frequency of the selected beneficial allele.
    • Initial allele frequency critically affects the likelihood of detecting selection signatures.

    Conclusions:

    • The model provides insights into the genetic consequences of artificial selection from standing variation.
    • Theoretical findings are relevant for interpreting empirical data, such as that from maize domestication.
    • The model is generalizable to other scenarios of selective sweeps from standing genetic variation.