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Related Experiment Video

Updated: Jul 10, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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[Papular purpuric gloves and socks syndrome. A case report].

A Manzi1, M T Saldutti, A Battista

  • 1Divisione di Pediatria, Ospedale S. Maria delle Grazie, ASL n. 2, Pozzuoli (Napoli), Italy.

Minerva Pediatrica
|July 14, 2004
PubMed
Summary
This summary is machine-generated.

Papulo-purpuric gloves and socks syndrome, linked to Parvovirus B19, is described in a pediatric case in Italy. This maculopurpuric exanthema warrants inclusion in differential diagnoses for similar skin conditions.

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Area of Science:

  • Pediatrics
  • Dermatology
  • Infectious Diseases

Background:

  • Papulo-purpuric gloves and socks syndrome (PGS) is a distinct maculopurpuric exanthema affecting hands and feet.
  • This condition is primarily associated with Parvovirus B19 infection.
  • Previous literature has not documented pediatric cases of PGS in Italy.

Observation:

  • A 10-year-old girl presented with classic symptoms of PGS.
  • Clinical presentation included a rash limited to the hands and feet.
  • Laboratory tests confirmed IgM positivity for anti-Parvovirus B19 antibodies.

Findings:

  • The reported case represents the first documented instance of PGS in a pediatric patient in Italy.
  • The patient's presentation and serological results strongly link PGS to Parvovirus B19 infection in this demographic.
  • The syndrome demonstrated spontaneous remission.

Implications:

  • This case highlights the importance of considering PGS in the differential diagnosis of maculopurpuric exanthemas in children in Italy.
  • Increased awareness may lead to earlier recognition and management of Parvovirus B19-associated dermatological manifestations.
  • Further surveillance may reveal a higher prevalence of PGS in the Italian pediatric population.