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[Suicidal fatal beta-blocker intoxication].

P Hilbert1, K Zur Nieden

  • 1Klinik für Anästhesiologie, Intensiv- und Notfallmedizin, BG-Kliniken Bergmannstrost Halle. Peter.Hilbert@bergmannstrost.com

Der Anaesthesist
|July 14, 2004
PubMed
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A 45-year-old female experienced beta-blocker intoxication from Talinolol. Despite initial stabilization, she developed cardiac arrest and died, highlighting the critical management of such overdoses.

Area of Science:

  • Cardiology
  • Clinical Toxicology

Background:

  • Beta-receptor antagonist (beta-blocker) overdose is a serious medical emergency.
  • Talinolol, a beta-blocker, can cause significant cardiovascular complications when taken in excess.

Observation:

  • A case of a 45-year-old female presenting with intentional Talinolol overdose (approximately 30 tablets).
  • Initial symptoms included hypotension, central nervous system effects, and cyanosis, but notably, no bradycardia.
  • The patient experienced cardiac arrest during treatment, both pre-hospital and shortly after hospital admission.

Findings:

  • Out-of-hospital management involved catecholamine (norepinephrine) administration for circulatory support.
  • Despite initial resuscitation efforts, including cardiopulmonary resuscitation (CPR), the patient ultimately succumbed to the intoxication in the intensive care unit.

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Implications:

  • This case underscores the potential severity of beta-blocker overdose, even with specific agents like Talinolol.
  • Effective pre-hospital and in-hospital management strategies are crucial for improving outcomes in beta-blocker intoxication.
  • The delayed onset of cardiac arrest highlights the need for continuous monitoring and aggressive supportive care.