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Published on: September 19, 2014
Spectroscopic detection of bladder cancer using near-infrared imaging techniques
Stavros G Demos1, Regina Gandour-Edwards, Rajen Ramsamooj
1Lawrence Livermore National Laboratory, Livermore, California 94551University of California Davis Medical School, Medical Center, Sacramento, California 95817, USA. demos1@llnl.gov
Abstract:
High-contrast imaging of bladder cancer is demonstrated using near-infrared autofluorescence under long-wavelength laser excitation in combination with cross-polarized elastic light scattering. Fresh unprocessed surgical specimens obtained following cystectomy or transurethral resection were utilized and a set of images for each tissue sample was recorded. These images were compared with the histopathology of the tissue sample. The experimental results indicate that the intensity of the near-infrared emission as well as that of the cross-polarized backscattered light was considerably different in cancer tissues than in that of the contiguous nonneoplastic tissues, allowing an accurate delineation of a tumor's margins.
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