Related Experiment Video
Updated: Aug 11, 2026

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
Published on: May 12, 2020
[The microbial flora in septic corneal ulcers]
1Clinica Oftalmologică Craiova.
Abstract:
The researching of the microbial flora for 101 septic ulcer of the cornea shows the highest frequency of gram-positive embryos, the golden Streptococcus has been met for 83 cases of which. The Streptococcus was for 7 cases, Pneumococcus for 2 cases, gram-positive Bacillus of superinfections for 14 cases. Among the gram-negative embryos might be mentioned Moraxella for 7 observations, Proteus for 4 obs., Klebsiella for 2 obs., Pseudomonas for 2 obs., Enterobacter for one case. For all the ulcers of the cornea it is obliged to be done the researching of the permeability of the lacrimal ways, the main source for infection of the cornea.
Insights
Microbial analysis of 101 corneal ulcers revealed Staphylococcus aureus as the most frequent pathogen. Researchers emphasize investigating lacrimal pathway permeability to identify the primary source of corneal infections.
Area of Science:
- Ophthalmology
- Microbiology
Context:
- Septic corneal ulcers represent a significant cause of vision impairment.
- Understanding the microbial etiology is crucial for effective treatment.
Purpose:
- To identify the predominant microbial pathogens in septic corneal ulcers.
- To highlight the importance of assessing lacrimal pathway integrity in corneal infections.
Summary:
- Analysis of 101 corneal ulcer cases identified gram-positive bacteria as the most common cause, with Staphylococcus aureus (golden Streptococcus) in 83 cases.
- Other identified gram-positive bacteria include Streptococcus (7 cases), Pneumococcus (2 cases), and gram-positive Bacillus (14 cases).
- Gram-negative bacteria such as Moraxella (7 cases), Proteus (4 cases), Klebsiella (2 cases), Pseudomonas (2 cases), and Enterobacter (1 case) were also detected.
Impact:
- This research underscores the need for comprehensive microbial investigations in corneal ulcer cases.
- It emphasizes the critical role of evaluating lacrimal pathway permeability as a potential source of infection, guiding diagnostic and therapeutic strategies.
Related Concept Videos
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Microbial Corrosion
The Skin Microbiota
Microbiome of the Eye
Microbiota of the Respiratory Tract
Microbiota of the Urogenital Tract

