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Related Experiment Videos

Changing trends in thyroid practice: understanding nodular thyroid disease.

Hossein Gharib1

  • 1Division of Endocrinology, Diabetes, Metabolism, Nutrition and, Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|July 15, 2004
PubMed
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Thyroid nodule evaluation has advanced significantly with improved thyroid function tests and diagnostic tools like fine-needle aspiration (FNA) biopsy. FNA is now the preferred initial diagnostic procedure for thyroid nodules.

Area of Science:

  • Endocrinology
  • Thyroidology
  • Diagnostic Medicine

Background:

  • Thyroid nodules are highly prevalent, especially in older adults, affecting over 100 million people in the US.
  • Significant advancements in thyroid function testing and diagnostic imaging have occurred over the past 50 years.

Purpose of the Study:

  • To review the evolution of thyroid nodule evaluation and management from 1952 to 2002.
  • To highlight key diagnostic and therapeutic developments in nodular thyroid disease.

Main Methods:

  • Review of personal experience, institutional contributions, and published literature.
  • Analysis of changes in thyroid function testing and nodule diagnostic strategies.

Main Results:

Related Experiment Videos

  • Development of sensitive thyroid function tests (TSH, T3, thyroxine assays) enabling early disease detection.
  • Introduction and validation of fine-needle aspiration (FNA) biopsy and ultrasonography as key diagnostic tools.
  • FNA biopsy has become the most accurate diagnostic test, reducing the need for surgery and potentially saving over $500 million annually in the US.

    • Conclusions:

    • Thyroid-stimulating hormone (TSH) is one of several factors in thyroid growth.
    • Fine-needle aspiration (FNA) biopsy is recommended as the initial diagnostic procedure for thyroid nodules due to its accuracy.