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Related Experiment Videos

Giant-cell granulomatous hypophysitis.

S Can1, T Tihan, J Alele

  • 1Endocrinology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|July 15, 2004
PubMed
Summary
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Giant-cell granulomatous hypophysitis is a rare inflammatory pituitary disorder. Corticosteroid treatment did not improve anterior pituitary function in a patient with this condition.

Area of Science:

  • Endocrinology
  • Neurology
  • Pathology

Background:

  • Giant-cell granulomatous hypophysitis (GCH) is a rare inflammatory disorder affecting the pituitary gland.
  • It can present as a pituitary mass with anterior pituitary dysfunction.

Purpose of the Study:

  • To describe the clinical features of GCH.
  • To evaluate the efficacy of corticosteroid treatment for GCH.

Main Methods:

  • A case of GCH was presented.
  • Pertinent literature was reviewed.
  • Magnetic resonance imaging (MRI) and transsphenoidal pituitary exploration with biopsy were performed.

Main Results:

  • A 41-year-old woman presented with anterior pituitary dysfunction and a pituitary mass.

Related Experiment Videos

  • MRI revealed a pituitary mass and thickened, enhancing pituitary stalk.
  • Biopsy confirmed GCH.
  • High-dose corticosteroid therapy did not reverse anterior pituitary dysfunction.

    • Conclusions:

    • A contrast-enhancing pituitary mass with a thickened stalk in young women may indicate an inflammatory pituitary condition like GCH.
    • Hypopituitarism in otherwise healthy young women without hormone hypersecretion should raise suspicion for GCH.
    • Corticosteroid treatment appears ineffective in improving anterior pituitary function in GCH.