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Asacol (mesalamine).

D Claussen

    Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates
    |August 1, 1992
    PubMed
    Summary
    This summary is machine-generated.

    Asacol, an oral mesalamine preparation, effectively treats mild to moderate ulcerative colitis by releasing 5-ASA in the ileum and colon. It offers an alternative for patients sensitive to sulfasalazine and may serve as a first-line therapy for inflammatory bowel diseases.

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    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Drug Delivery Systems

    Background:

    • Ulcerative colitis is a chronic inflammatory bowel disease affecting the colon.
    • Current treatments include sulfasalazine, which can have dose-limiting side effects.
    • There is a need for effective and well-tolerated therapies for ulcerative colitis.

    Purpose of the Study:

    • To evaluate Asacol (mesalamine) as a treatment for mildly to moderately active ulcerative colitis.
    • To assess the efficacy of a pH-sensitive, delayed-release oral preparation of 5-ASA.

    Main Methods:

    • Asacol is an oral preparation of 5-ASA with a pH-sensitive, polymer coating.
    • The formulation is designed for targeted drug release in the terminal ileum and colon.
    • Clinical efficacy was assessed in patients with mild to moderate ulcerative colitis.

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    Main Results:

    • Asacol delivers 5-ASA (mesalamine) to the distal ileum and colon.
    • The delayed-release formulation targets inflammation in the lower gastrointestinal tract.
    • Treatment modalities using Asacol show promise for ulcerative colitis management.

    Conclusions:

    • Asacol provides a targeted delivery of mesalamine for ulcerative colitis.
    • It serves as a viable alternative for sulfasalazine-intolerant patients.
    • Asacol represents a potential first-line therapy for inflammatory bowel diseases.