Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Junctions and vesicular trafficking during Drosophila cellularization.

Thomas Lecuit1

  • 1Laboratoire de Génétique et de Physiologie du Développement, UMR 6545 CNRS-Université de la Méditerranée, Institut de Biologie du Développement de Marseille, Campus de Luminy, case 907, 13288 Marseille CEDEX 09, France. lecuit@ibdm@univ-mrs.fr

Journal of Cell Science
|July 15, 2004
PubMed
Summary

Drosophila embryo cellularization, a hybrid cleavage, forms an epithelial layer essential for development. Novel proteins Nullo and Slam regulate membrane growth during this critical process.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical regulation of cuboidal-to-squamous epithelial transition in the Drosophila developing wing.

Current biology : CB·2026
Same author

Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation.

Nature communications·2026
Same author

The hard truth about how hard it is to publish in Development.

Development (Cambridge, England)·2026
Same author

Mechanical regulation of substrate adhesion and de-adhesion drives a cell-contractile wave during Drosophila tissue morphogenesis.

Developmental cell·2023
Same author

Serotonin signaling regulates actomyosin contractility during morphogenesis in evolutionarily divergent lineages.

Nature communications·2023
Same author

Growth anisotropy of the extracellular matrix shapes a developing organ.

Nature communications·2023

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Cellularization in Drosophila embryos is a unique process converting a syncytium into distinct cells.
  • This process is crucial for epithelial biogenesis and subsequent embryonic development, including gastrulation.
  • Defects in cellularization severely impact tissue remodeling and overall development.

Purpose of the Study:

  • To investigate the mechanisms underlying cellularization in Drosophila embryos.
  • To identify key regulators of membrane growth and epithelial formation during this process.
  • To understand the roles of novel proteins Nullo and Slam in cellularization.

Main Methods:

  • Utilized genetic approaches to study cellularization.
  • Examined conserved cellular pathways involved in vesicular trafficking (biosynthetic and endocytic).

Related Experiment Videos

  • Investigated the function of newly identified proteins, Nullo and Slam.

    • Main Results:

    • Cellularization involves plasma membrane invagination, basal-lateral surface formation, and apical adherens junction assembly.
    • Regulated vesicle mobilization is essential for membrane growth and surface polarization.
    • Nullo and Slam are novel developmental regulators specifically induced during cellularization, controlling membrane growth.

    Conclusions:

    • Drosophila cellularization is a complex process requiring coordinated membrane dynamics and conserved cellular pathways.
    • The proteins Nullo and Slam play critical roles as developmental regulators of membrane expansion during cellularization.
    • Understanding these mechanisms provides insights into epithelial development and related disorders.