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A longitudinal study of joint pain in older people

I P Donald1, C Foy

  • 1Elderly Care, Gloucestershire Hospitals NHS Trust, Gloucester GL1 3NN, UK. ecare@blueyonder.co.uk

Abstract

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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