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Related Experiment Videos

Acute marijuana effects on response-reinforcer relations under multiple variable-interval schedules.

S D Lane1, D R Cherek, C J Pietras

  • 1Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX 77030, USA. scott.d.lane@uth.tmc.edu

Behavioural Pharmacology
|July 15, 2004
PubMed
Summary

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Acute marijuana use may impair motor skills and reduce the perceived value of rewards. High doses specifically affected response rates and decreased the efficacy of reinforcers in human subjects.

Area of Science:

  • Behavioral pharmacology
  • Human psychopharmacology

Background:

  • Acute marijuana administration may affect the relationship between responses and reinforcers, potentially by altering reinforcer efficacy or impairing motor function.
  • The matching law is a valuable tool for analyzing drug effects on both motor control and reward valuation.

Purpose of the Study:

  • To investigate the effects of acute marijuana administration on response properties and reinforcer efficacy in humans using the matching law framework.
  • To differentiate between potential alterations in motor function and changes in subjective value of reinforcers.

Main Methods:

  • Six human participants completed a multiple variable interval (VI) schedule task for monetary reinforcement.
  • Participants smoked a placebo or one of two active doses of marijuana.

Related Experiment Videos

  • Behavioral data were analyzed using parameters from the matching law equation (k and rB) to assess response rate and reinforcer efficacy.

    • Main Results:

    • A low dose of marijuana resulted in unsystematic changes in responding.
    • At a high dose, five participants exhibited decreased response rates, suggesting impaired motor function.
    • Four participants showed decreased reinforcer efficacy at the high dose, indicating a reduced value of the monetary reward.

    Conclusions:

    • High doses of marijuana may impair motor coordination, affecting response rates.
    • Acute marijuana administration at high doses can decrease the perceived efficacy of reinforcers.
    • These findings suggest that marijuana's effects extend to both motor performance and the subjective valuation of rewards.