Trisomy 1 in a case of a missed abortion
Michio Banzai1, Satoshi Sato2, Hideo Matsuda3
1Department of Obstetrics and Gynecology, Saiseikai Yamagata Hospital, 79-1 Okimachi, Yamagata 990-8545, Japan. banzai@macbase.or.jp.
Abstract:
Most chromosomal trisomies lead to miscarriages. In all trisomies, trisomy 1 is the most rare case. We herein present a patient who demonstrated a gestational sac and a yolk sac on transvaginal ultrasound. However, at 53 days of gestation, the pregnancy was lost with a diagnosis of a blighted ovum. A D&C was recommended and performed. A cytogenetic analysis from chorionic villi demonstrated a 47,XX,+1 chromosome complement in all 100 cells. Regarding full trisomy 1, there has only been one case report of a preembryo and two case reports in a clinically recognized pregnancy to date.
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