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Left hemispheric activation in depersonalization disorder: a case report
E Hollander1, J L Carrasco, L S Mullen
1Columbia University Department of Psychiatry, New York, New York.
Biological Psychiatry
|June 1, 1992
Summary
This study explores the neurobiology of depersonalization disorder, finding unique brain patterns in a patient. These findings suggest similarities between depersonalization disorder and obsessive-compulsive disorder.
Area of Science:
- Neuroscience
- Psychiatry
- Dissociative Disorders
Background:
- Depersonalization disorder, a dissociative disorder, involves altered self-perception.
- Neurobiological correlates of depersonalization disorder remain largely unexplored.
- Previous treatment trials with anticonvulsants, MAOIs, and TCAs were ineffective for the patient.
Observation:
- A single patient with depersonalization disorder was treated with fluoxetine.
- Fluoxetine partially alleviated depersonalization symptoms but not comorbid anxiety or depression.
- Comprehensive neurobiological assessments were conducted.
Findings:
- Neurophysiological, neuroanatomical, and neuropsychological evaluations revealed distinct brain activity.
- Key findings include left hemispheric frontal-temporal activation.
- A decrease in left caudate perfusion was also observed.
Implications:
- The observed neurobiological patterns in depersonalization disorder show similarities to those in obsessive-compulsive disorder.
- This suggests potential shared neurobiological mechanisms between these conditions.
- Further research into these similarities could inform novel treatment strategies.