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Updated: Aug 23, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Removal of mandibular tooth follicles before distraction osteogenesis
Eran Regev1, John N Jensen, Joseph G McCarthy
1Department of Oral and Maxillofacial Surgery, Hadassah, Hebrew University Medical Center, Jerusalem, Israel.
Abstract:
Distraction osteogenesis is an innovative technique that has transformed the treatment of craniofacial malformations in young children. Bone generation obviates the need for graft material, which is in short supply in young patients, thus making possible surgical procedures on the craniofacial skeleton in young children. Sufficient mandibular volume is required for the osteotomy and placement of the device screws and/or pins. To have adequate bone stock and to facilitate distraction, the authors preoperatively examined all patients radiographically and selected those with tooth follicles that precluded successful osteotomy and pin placement for planned mandibular distraction. This report is of the first 13 children, aged 9 months to 6 years, who underwent predistraction enucleation. The osteotomy and device placement were performed successfully at least 4 months after enucleation. The described procedure has minimal morbidity and has resulted in successful subsequent distraction. The advantages, disadvantages, and cost-benefit issues are discussed.
