Carcinosarcoma of the maxilla in a squirrel monkey (Saimiri sciureus)
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Updated: Aug 23, 2026

Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
Published on: April 3, 2026
Niki M Moutsopoulos1, Nikolaos G Nikitakis, Douglas A Powell
1Department of Periodontics, University of Maryland Dental School, 666 W Baltimore St., Baltimore, Maryland 21201, USA.
Abstract:
We present the first, to our knowledge, described case of carcinosarcoma of the maxilla in a squirrel monkey. Carcinosarcomas are rare tumors of the upper aerodigestive tract, and consist of carcinomatous and sarcomatous tissue. Histologic analysis revealed a neoplasm composed of an adenocarcinomatous component (epithelial element) and a mesenchymal component (sarcomatous element). Metastatic growth was documented in the lung tissue and the submandibular lymph node. The histolopathologic findings, the pattern of metastasis, and the clinical progression closely resembled those of carcinosarcoma involving salivary glands in humans.

