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Carcinosarcoma of the maxilla in a squirrel monkey (Saimiri sciureus)
Niki M Moutsopoulos1, Nikolaos G Nikitakis, Douglas A Powell
1Department of Periodontics, University of Maryland Dental School, 666 W Baltimore St., Baltimore, Maryland 21201, USA.
Comparative Medicine
|July 16, 2004
Summary
This study details the first known case of carcinosarcoma, a rare dual-tissue tumor, in a squirrel monkey's maxilla. The findings show similarities to human salivary gland carcinosarcomas, including metastasis.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
Background:
- Carcinosarcomas are rare malignant neoplasms characterized by the simultaneous presence of carcinomatous and sarcomatous components.
- Tumors of the upper aerodigestive tract, particularly in non-human primates, are infrequently documented.
Observation:
- A unique case of carcinosarcoma affecting the maxilla in a squirrel monkey is described.
- Histologic examination confirmed a biphasic tumor comprising an adenocarcinomatous (epithelial) and a sarcomatous (mesenchymal) element.
Findings:
- Metastatic spread of the carcinosarcoma was identified in the lung tissue and a submandibular lymph node.
- The observed histopathologic features, metastatic pattern, and clinical course closely mirrored human salivary gland carcinosarcomas.
Implications:
- This case expands the understanding of carcinosarcoma occurrence in non-human primates.
- It highlights the potential for comparative oncology studies between squirrel monkeys and humans regarding this rare tumor type.