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Updated: Aug 9, 2026
Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
Published on: January 20, 2010
[Histopathological changes at the surgical site in experimental animals following partial cricoid resection and
E Morera1, H Alvarez, L Fontes
1Médico Especialista en ORL, Instituto Antolí-Candela. morera@hotmail.com
Objective:
To study in an animal model the local healing process after partial cricoid resection with thyrotracheal anastomosis.
Material And Methods:
Partial cricoid resection with thyrotracheal anastomosis was performed in 17 New Zealand rabbits. Experimental animals were gradually sacrificed and the laryngotracheal complex was removed to proceed to a histopathological study.
Results:
An acute inflammatory response followed by a chronic inflammatory process was found in the surgical site. Normal tissue architecture was established after an eight week period. Anteroposterior and transverse diameters at all levels of the upper respiratory tract were not significantly altered at any time along the healing process. Experimental animals remained free from symptoms during the follow-up period.
Conclusions:
These results support that partial cricoid resection with thyrotracheal anastomosis is a safe procedure for the treatment of severe laryngotracheal stenosis.
