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Updated: Aug 10, 2026

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia
Published on: August 8, 2013
[Ciliary changes with abscence of dynein arms in Kartagener's syndrome]
P Melgarejo Moreno1, X Galindo Ortego, L Marqués Amat
1Unitat d'Al-lergologia, Hospital de Santa María de Lleida.
Abstract:
A 33 years-old female with a diagnosis of Kartagener's syndrome was studied. She had a clinical history of chronic sinusitis with nasal obstruction and rhinorrea, and a chronic cough with mucopurulent sputum. A paranasal sinus CT showed hypertrophyc mucosa. A thoracic CT showed a situs inversus and chronic bronchitis with bronchiectasis. The saccharin test lasted 55 minutes. The electron microscopy study showed in a a cross-sectional axoneme a total absence of the outer and inner arm of the 9th outer doublet in over a 100 cilias studied. No others ultrastructure anormalities were observed.
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The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
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