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The effects of peripherally administered chloroquine on body temperature

T Y Lot1

  • 1Department of Physiology and Pharmacology, Queen's Medical Center, Nottingham, England.

In Vivo (Athens, Greece)
|March 1, 1992
PubMed

Insights

Chloroquine diphosphate lowers body temperature in young chicks, with effects decreasing as the birds age. This hypothermic action may explain its fever-reducing effects in malaria.

Area of Science:

  • Pharmacology
  • Animal Physiology
  • Thermoregulation

Background:

  • Chloroquine is an antimalarial drug with known effects on body temperature.
  • Understanding the mechanisms of drug-induced thermoregulation is crucial for therapeutic applications.

Purpose of the Study:

  • To investigate the impact of chloroquine diphosphate on body temperature in newly hatched chicks.
  • To determine the age-dependency of chloroquine's hypothermic effects.

Main Methods:

  • Administration of varying doses of chloroquine diphosphate to chicks of different ages.
  • Measurement of central and peripheral body temperatures following drug administration.

Main Results:

  • Chloroquine diphosphate significantly reduced both central and peripheral body temperatures in chicks.
  • The hypothermic effect was dose-dependent and most pronounced in chicks under 6 days old.
  • Thermoregulatory response to chloroquine diminished with increasing age.

Conclusions:

  • Chloroquine diphosphate exhibits a dose-dependent hypothermic effect in young chicks.
  • The observed hypothermia in chicks may contribute to chloroquine's antipyretic properties, particularly in managing malaria-associated fever.

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