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Platelet-activating factor in Japanese cedar pollinosis
T Nakamura1, K Ishihara, M Kuriyama
1Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
Journal of Lipid Mediators
|June 1, 1992
Summary
Platelet-activating factor (PAF) may play a key role in Japanese cedar pollinosis. Lyso-PAF levels decreased with ketotifen treatment, suggesting anti-PAF action contributes to the drug's effectiveness in treating this allergy.
Area of Science:
- Immunology
- Allergology
- Pharmacology
Background:
- Japanese cedar pollinosis is a prevalent allergic condition.
- Platelet-activating factor (PAF) is implicated in allergic responses.
- Lyso-PAF, a metabolite of PAF, serves as a biomarker.
Purpose of the Study:
- To investigate the role of lyso-PAF in Japanese cedar pollinosis.
- To assess the effect of ketotifen, an anti-allergic drug, on lyso-PAF levels.
Main Methods:
- Serum lyso-PAF concentrations were measured in patients with Japanese cedar pollinosis and healthy controls.
- Serum lyso-PAF levels were analyzed before and after treatment with ketotifen.
Main Results:
- Untreated patients with Japanese cedar pollinosis exhibited significantly higher serum lyso-PAF levels compared to healthy controls.
- Ketotifen therapy led to a significant reduction in serum lyso-PAF levels in patients with Japanese cedar pollinosis.
Conclusions:
- PAF appears to be involved in the pathophysiology of Japanese cedar pollinosis.
- The therapeutic efficacy of ketotifen may be partly attributed to its anti-PAF activity.