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Updated: Aug 23, 2026

Visualization of Cell Cycle Variations and Determination of Nucleation in Postnatal Cardiomyocytes
Published on: February 24, 2017
Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes
Katrina A Bicknell1, Carmen H Coxon, Gavin Brooks
1Cardiovascular Research Group, School of Pharmacy, The University of Reading, P.O. Box 228, Whiteknights, Reading, Berkshire RG6 6AJ, UK.
Abstract:
Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.
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