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Related Experiment Videos

Amphetamine-induced chorea in attention deficit-hyperactivity disorder.

John C Morgan1, W Christopher Winter2, G Frederick Wooten2

  • 1Medical College of Georgia, Department of Neurology, Augusta, Georgia, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|July 16, 2004
PubMed
Summary

Stimulant medications for attention deficit-hyperactivity disorder (ADHD) can rarely cause chorea, a movement disorder. This case report details an adult ADHD patient who experienced chorea after increasing their mixed amphetamine salts dosage.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Attention deficit-hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
  • Stimulant medications, such as mixed amphetamine salts, are frequently prescribed for ADHD in adults.
  • While stimulant-induced tics are known, other movement disorders like chorea are rarely reported.

Observation:

  • An adult patient with ADHD experienced new-onset choreiform movements.
  • The chorea developed after a dose escalation of mixed amphetamine salts.
  • The movement disorder resolved upon discontinuation of the medication.

Findings:

  • This case highlights a rare adverse effect of stimulant medication in ADHD treatment.
  • Mixed amphetamine salts, at higher doses, may precipitate chorea in susceptible individuals.

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  • The temporal relationship suggests a causal link between the medication and the choreiform movements.

    • Implications:

    • Clinicians should be aware of the potential for chorea as a rare complication of stimulant therapy for ADHD.
    • Careful monitoring for movement abnormalities is warranted during dose adjustments of mixed amphetamine salts.
    • Further research may explore the mechanisms underlying stimulant-induced chorea and identify risk factors.