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Published on: September 5, 2016
Drug-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: a concise review
Jeffrey S Dlott1, Constance F M Danielson, Deborah E Blue-Hnidy
1Department of Pathology and Laboratory Medicine (Transfusion Medicine), Indiana University School of Medicine, Indianapolis, IN, USA.
Abstract:
An extensive variety of drugs have been associated with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP/HUS). Although a direct causal effect has usually not been proven, the cumulative evidence linking several drugs with TTP/HUS is strong. This paper reviews several categories of drugs including antineoplastics, immunotherapeutics and anti-platelet agents that have been reported to induce TTP/HUS. The pathogenesis of drug-induced TTP/HUS and the effectiveness of treatment regimens are also reviewed. A consensus on diagnostic criteria to accurately and consistently diagnose drug-induced TTP is needed.
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