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[Detection of transfusion transmitted virus (TTV) DNA in sera among three different population groups in Abidjan,
E Ekaza1, N C Ogniangué, A Kouassi-M'Bengue
1Unité de microbiologie moléculaire, Laboratoire de bactériologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire. ekazae@hotmail.com
Insights
Transfusion-transmitted Virus (TTV) is highly prevalent in Abidjan, Côte d'Ivoire. This study found high TTV detection rates in multitransfused patients and those with chronic liver disease.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Transfusion-transmitted Virus (TTV) is a widespread human virus.
- Understanding TTV prevalence is crucial for blood safety and public health strategies.
- Limited data exists on TTV prevalence in West African populations.
Purpose of the Study:
- To determine the prevalence of TTV in different population groups in Abidjan, Côte d'Ivoire.
- To investigate TTV infection in multitransfused patients, healthy blood donors, and patients with chronic liver disease.
- To establish baseline TTV prevalence data for the Ivorian population.
Main Methods:
- Polymerase Chain Reaction (PCR) was used to detect TTV DNA in patient serum samples.
- Three distinct population groups were studied: multitransfused patients (n=39), healthy blood donors (n=10), and patients with chronic liver disease (n=43).
- The chronic liver disease group included patients with positive serology for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV).
Main Results:
- High detection rates of TTV were observed across the studied groups, ranging from 67% to 82%.
- The study provides the first evidence of high TTV carriage in the Ivorian population.
- Specific prevalence rates varied between the multitransfused and chronic liver disease patient groups.
Conclusions:
- TTV infection is highly prevalent in Abidjan, Côte d'Ivoire.
- The findings highlight the importance of considering TTV in transfusion safety and clinical management in the region.
- Further research is warranted to understand TTV transmission dynamics and clinical implications in Côte d'Ivoire.
Abstract:
The aim of this study was to determine the transfusion transmitted Virus (TTV) prevalence in three groups of population from Abidjan, Côte d'Ivoire. The A group contained 39 multitransfused patients, the B group contained 10 blood donors supposed to be healthy persons which have never been transfused and the group C contained 43 patients with chronic liver pathology. In this last group, 33 patients had HBV positive serology and the 10 others, HCV positive serology. We used PCR to investigate TTV in patients serum. Detection rates were comprised between 67% and 82%. This is the first study to provide information about the high portage of TTV in ivorian population.
