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Possible role of Granulocyte Macrophage Colony Stimulating Factor receptor (GM-CSF R) in malaria

N Ananth1, Beena V Shetty, D M Vasudevan

  • 1Department of Biochemistry, Center for Basic Sciences, Kasturba Medical College, Bejai, Mangalore, 575 001, India. gmcsf@operamail.com

Indian Journal of Experimental Biology
|July 17, 2004
PubMed

Insights

This study found no significant changes in granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor levels during malaria diagnosis or treatment. Therefore, the GM-CSF receptor does not appear to play a major role in Plasmodium vivax or Plasmodium falciparum malaria.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Parasitology

Background:

  • Malaria incidence is increasing globally, with cytokines implicated in cerebral malaria pathogenesis.
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates tumor necrosis factor alpha (TNF alpha), a pyrogenic cytokine.

Purpose of the Study:

  • To investigate the potential role of the GM-CSF receptor in the pathogenesis of Plasmodium vivax and Plasmodium falciparum malaria.

Main Methods:

  • Utilized a laboratory-developed enzyme immunoassay to quantify GM-CSF receptor concentrations.
  • Measured receptor levels at diagnosis and post-treatment in malaria patients.

Main Results:

  • No significant alterations in GM-CSF receptor concentration were observed at diagnosis or after treatment.
  • No significant difference in receptor concentration was found between Plasmodium vivax and Plasmodium falciparum groups.

Conclusions:

  • The GM-CSF receptor does not appear to have a significant role in the pathogenesis of either Plasmodium vivax or Plasmodium falciparum malaria.

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