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Related Experiment Videos

Tissue growth and remodeling.

Stephen C Cowin1

  • 1The New York Center for Biomedical Engineering and the Department of Biomedical, School of Engineering, City College and Graduate School, The City University of New York, New York 10031, USA. scowin@earthlink.net

Annual Review of Biomedical Engineering
|July 17, 2004
PubMed
Summary
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Tissue growth and remodeling are influenced by mechanical forces and genetics. Mechanical stress from tissue use promotes development, while disuse hinders it, impacting tissue structure and protein formation.

Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Developmental Biology

Background:

  • Tissue growth and remodeling are complex processes influenced by both genetic and environmental factors.
  • The mechanical environment plays a crucial role in shaping tissue morphology, size, and composition.
  • Understanding these interactions is key to advancing regenerative medicine and understanding developmental processes.

Purpose of the Study:

  • To explore the interplay between mechanical stimuli, genetic information, and epigenetic mechanisms in tissue development.
  • To review existing mechanical and mathematical models for simulating tissue growth and remodeling.
  • To highlight the impact of tissue use and disuse on developmental trajectories.

Main Methods:

  • Review of literature on tissue mechanics, genetics, and developmental biology.

Related Experiment Videos

  • Analysis of the influence of mechanical loading on cellular processes and protein synthesis.
  • Examination of mathematical and computational modeling approaches, including cellular automata and continuum mechanics.

    • Main Results:

    • Mechanical environment significantly impacts tissue morphology, growth, and protein synthesis.
    • Tissue use enhances developmental growth and remodeling, whereas disuse leads to retardation.
    • Genetic and epigenetic factors are integral to the tissue's response to mechanical cues.

    Conclusions:

    • Mechanical forces are critical regulators of tissue development, interacting with genetic blueprints.
    • Mathematical models provide valuable tools for predicting and understanding tissue growth dynamics.
    • Optimizing mechanical stimuli is essential for effective tissue engineering and therapeutic interventions.