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Related Experiment Videos

Thyroid function after autologous bone marrow transplantation.

K Carlson1, G Lönnerholm, B Smedmyr

  • 1Department of Internal Medicine, University Hospital, Uppsala, Sweden.

Bone Marrow Transplantation
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

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Autologous bone marrow transplantation (ABMT) can affect thyroid function, particularly in patients receiving total body irradiation (TBI). Monitoring thyroid-stimulating hormone (TSH) is crucial for detecting dysfunction post-ABMT.

Area of Science:

  • Endocrinology
  • Hematology
  • Oncology

Background:

  • Autologous bone marrow transplantation (ABMT) is a complex procedure with potential long-term effects.
  • Thyroid dysfunction is a recognized complication following bone marrow transplantation.
  • Understanding the specific impact of ABMT on thyroid function is essential for patient management.

Purpose of the Study:

  • To prospectively evaluate thyroid function in patients undergoing autologous bone marrow transplantation (ABMT).
  • To determine the incidence and characteristics of thyroid dysfunction after ABMT.
  • To assess the influence of total body irradiation (TBI) as part of conditioning on thyroid function.

Main Methods:

  • Prospective analysis of thyroid function in 111 consecutive patients undergoing ABMT.

Related Experiment Videos

  • Measurement of thyroxine, triiodothyronine, thyrotropin (TSH), and thyroid antibodies before ABMT and at regular intervals post-transplant.
  • Comparison of thyroid function between patients who received TBI and those who did not.

    • Main Results:

    • Thyroid dysfunction was observed in 20 patients (18.0%), with a higher incidence in those who received TBI (16/58) compared to non-TBI treatments (4/53).
    • Five patients (all TBI) developed primary hypothyroidism, and 15 experienced compensated hypothyrosis, which was transient in eight.
    • A significant increase in median TSH levels was noted one year post-ABMT compared to pre-ABMT levels, particularly in patients who developed thyroid dysfunction.

    Conclusions:

    • Autologous bone marrow transplantation, especially with TBI, is associated with a significant risk of thyroid dysfunction.
    • Monitoring TSH levels before and after ABMT is critical for early detection and management of thyroid abnormalities.
    • The findings suggest a need for routine thyroid function assessment in ABMT survivors.