Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ovarian tumors with endocrine function].

Li-Na Guo1, Tong-Hua Liu, Ai-Jun Sun

  • 1Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. guoln@pumch.ac.cn

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|July 17, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined Aspergillus-specific IgG and galactomannan testing optimizes diagnosis of invasive pulmonary aspergillosis in non-neutropenic patients.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2026
Same author

Carbocycle editing of ketones proceeds via a radical-mediated bidirectional C-C bond cleavage/coupling strategy.

Nature communications·2026
Same author

Development and Reliability Test of the Intravenous Thrombolysis Intention Scale for Patients With Acute Ischemic Stroke.

Nursing open·2026
Same author

Iron-Catalyzed Radical-Mediated 1,3-Azidoalkylation of Bicyclo[1.1.0]butanes: Access to 1,1,3,3-Tetrasubstituted Cyclobutanes via Strain Release.

Organic letters·2026
Same author

Is there a correlation between male partner's previous tuberculosis and recurrent pregnancy loss (RPL)? - a single-center retrospective analysis.

Open medicine (Warsaw, Poland)·2026
Same author

Photoinduced three-component alkylpyridination of alkenes <i>via</i> spiro-dihydroquinazolinone fragmentation.

Chemical communications (Cambridge, England)·2026
Same journal

[The application of single-cell omics and spatial omics in investigating tumor microenvironment heterogeneity of non-small cell lung cancer].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[Value of p53 immunohistochemistry in diagnosing esophageal squamous intraepithelial neoplasia].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[Pulmonary immunoglobulin-storing histiocytosis: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[Multiple recurrences with orbital invasion arising from primary sinonasal solitary fibrous tumor: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[Primary choriocarcinoma of the liver metastasizes to the gallbladder and gallbladder adenosquamous cell carcinoma with enteroblastic differentiation: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same journal

[GLI1 rearrangement in colon tumor: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
See all related articles

Endocrinologically active ovarian tumors, primarily sex cord-stromal tumors, often overproduce sex steroids. Immunohistochemistry markers like alpha-inhibin and calretinin aid in diagnosing these functional ovarian neoplasms.

Area of Science:

  • Gynecologic Oncology
  • Endocrinology
  • Pathology

Background:

  • Ovarian tumors can exhibit endocrine activity, primarily through sex steroid overproduction.
  • Understanding the clinicopathological features of these functional ovarian neoplasms is crucial for diagnosis and management.

Purpose of the Study:

  • To analyze the clinicopathological features of ovarian tumors with endocrine function.
  • To evaluate the utility of immunohistochemistry in diagnosing ovarian sex cord-stromal tumors.

Main Methods:

  • Review of 24 cases of ovarian tumors with endocrine manifestations.
  • Histopathological evaluation and immunohistochemistry staining (AE1/AE3, EMA, alpha-inhibin, calretinin, SMA).

Main Results:

Related Experiment Videos

  • Most functional ovarian tumors were sex cord-stromal tumors, often small to medium in size.
  • Clinical manifestations correlated with sex steroid overproduction, not histological subtype.
  • Alpha-inhibin and calretinin were positive in sex cord-stromal tumors; EMA negativity helped differentiate from epithelial tumors.

    • Conclusions:

    • Functional ovarian tumors are predominantly sex cord-stromal tumors, but non-sex cord-stromal types can also be functional.
    • Alpha-inhibin and calretinin are valuable immunohistochemical markers for diagnosing ovarian sex cord-stromal tumors.
    • EMA negativity is a useful feature for distinguishing these tumors from ovarian epithelial neoplasms.