Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antiepileptic drugs and memory.

Gholam K Motamedi1, Kimford J Meador

  • 1Department of Neurology, Georgetown University School of Medicine, Washington, DC, USA.

Epilepsy & Behavior : E&B
|July 17, 2004
PubMed
Summary

Antiepileptic drugs (AEDs) can impair memory in epilepsy patients, independent of mood or epilepsy itself. Further research is needed to understand these drug effects, especially in diverse populations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic Testing in Adult Patients With Epilepsy: Genetic Risk Index for Seizure Etiology for Identifying Optimal Candidates.

Neurology. Clinical practice·2026
Same author

Maternal and umbilical cord plasma concentrations of antiseizure medications: Results from the observational MONEAD study.

Epilepsia·2026
Same author

Predicting seizure freedom in the postpartum period: Findings from the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs study.

Epilepsia·2026
Same author

Prenatal Azithromycin Exposure and Risk of Neurodevelopmental Disorders in Children.

JAMA network open·2026
Same author

Malformations and Fetal Exposures to Antiseizure Medication Polytherapies.

Neurology·2026
Same author

CORE-VNS: Dosing and titration of VNS therapy in contemporary clinical practice.

Epilepsy & behavior reports·2026

Area of Science:

  • Neuroscience
  • Clinical Pharmacology
  • Epileptology

Background:

  • Memory impairment is a frequent complaint in epilepsy patients.
  • Multiple factors, including mood and epilepsy itself, complicate assessing antiepileptic drug (AED) effects on memory.
  • Existing evidence suggests AEDs may independently impair memory, based on animal and healthy volunteer studies.

Purpose of the Study:

  • To review the evidence for antiepileptic drug-induced memory impairment in epilepsy patients.
  • To highlight methodological challenges in studying AED effects on memory in clinical settings.
  • To identify gaps in knowledge regarding AEDs and memory, particularly in specific populations.

Main Methods:

  • Literature review of studies investigating memory function in epilepsy patients using antiepileptic drugs.
  • Analysis of factors influencing memory perception and objective memory assessment.
  • Examination of differential effects of various AEDs on memory.

Main Results:

  • Antiepileptic drugs (AEDs) show potential to impair memory, separate from mood or epilepsy-related factors.
  • Observed differential effects among AEDs on memory function.
  • Memory impairment concerns are heightened at the age extremes, with limited data on newer agents.

Conclusions:

  • Antiepileptic drugs (AEDs) can independently affect memory in epilepsy patients.
  • Methodological rigor is needed to disentangle AED effects from other contributing factors.
  • Further well-controlled studies are essential to clarify AED-related memory risks across patient demographics.

Related Experiment Videos