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Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study
Kiran T Kumar1, A Chandrika, Krishna N Sumanth
1Department of Biochemistry, Kasturba Medical College and Hospital, Manipal-576 104, Karnataka, India.
Background:
The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a vast array of disease processes including some neurological disorders.
Method:
Ten patients with Guillain-Barre syndrome (GBS) and 10 age and sex-matched controls were included in this study. The erythrocyte glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) levels, as well as plasma antioxidant vitamins C and E and serum glutathione-S-transferase (GST) levels were estimated spectrophotometrically.
Results:
The plasma vitamin E and the serum total glutathione-S-transferase levels were markedly increased in both pre- and post-treated cases of GBS when compared to controls. The erythrocyte glutathione and malondialdehyde levels were significantly reduced in GBS cases when compared to normals. However, plasma vitamin C and erythrocyte superoxide dismutase were not altered when compared to controls.
Conclusion:
Free radical toxicity may have an influence in patients suffering from GBS.
