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Morphological features of degenerating oligodendrocytes in twitcher mice
1Department of Physiology, University of Kansas Medical Center, Kansas City 66160.
Brain Research
|August 7, 1992
Abstract:
The morphological features of degenerating oligodendrocytes in twitcher mice were examined by a modified iron histochemical technique. Oligodendrocytes in twitcher mice were found to have several features distinct from oligodendrocytes in normal mice; swellings at different sites along their processes, swollen soma and an increase in iron-rich, oval structures in their cytoplasm. In addition to changes in oligodendrocyte morphology, endothelial cells in brains of twitcher mice were found to be highly enriched with iron.